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KMID : 0370220060500060345
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Yakhak Hoeji
2006 Volume.50 No. 6 p.345 ~ p.350
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Antidiabetic Activity of IH-901 in db/db Mice
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Choi Yun-Sook
Han Eun-Jung
Park Keum-Ju
Han Ki-Chul
Park Jonh-Suk
Chung Sung-Hyun
Sung Jong-Hwan
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Abstract
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The pharmacological properties of ginseng are mainly attributed to ginsenosides, the active constituents that are found in the extracts of different species of ginseng. Lately, the studies on ginsenosides are mainly focused on IH-901, a major intestinal bacterial metabolite of ginsenosides. In this study, we examined the anti-diabetic activity of IH-901 in C57BL/6J db/db mice model. IH-901 was administrated orally at a dose of 20 mg/kg for weeks. During the experimental period, body weight and blood glucose levels were measured every week. After 5 weeks, db/db mice were sacrificed and diabetic parameters were analyzed. IH-901 treated group showed a significant decrease in fasting blood glucose levels (from 10.5 mM to 9.4 mM), insulin resistance index (from 163.6 to 100.2) and triglyceride levels (from 115.3 to 70.1) compared to the diabetic control. In pancreatic islets morphology, IH-901 recovered β-cell damage due to hyperglycemia. In addition, IH-901 upregulated expressions of glucose transporter 4 (GLUT4) and PPAR-γ in skeletal muscle and adipose tissue, respectively. Taken together, IH-901 might be a potential anti-hyperglycemic agent with insulin sensitizing effect.
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KEYWORD
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ginsenosides, IH-901, anti-diabetic activity, db/db mice, glucose transporter(GLUT4), PPAR-γ
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